Y o sex

Quiz In the nucleus of every cell of his or her body, a human being has 46 chromosomes. They are denoted as X and Y. A female has two X-chromosomes and a male an X and a Y-chromosome. In a woman, one of the two X-chromosomes is inactivated in the form of heterochromatin sex chromatin , the Barr body - diagnosis of the genetic gender is made on this basis. This inactivation already takes place in the blastocyst stage 3 - randomly - either on the paternal or maternal X chromosome.

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21.1 Genetic factors and hormones that determine gender

WHO | Gender and Genetics

GH and sex hormones are critical regulators of body growth and composition, somatic development, intermediate metabolism, and sexual dimorphism. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Effects of sex hormones on the liver may be direct, through hepatic receptors, or indirect by modulating endocrine, metabolic, and gender-differentiated functions of GH. Sex hormones can modulate GH actions by acting centrally, regulating pituitary GH secretion, and peripherally, by modulating GH signaling pathways.
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Y chromosome

Sex Chromosome Abnormalities. The majority of known types of chromosomal abnormalities involve sex chromosomes. In frequency of occurrence, they are only slightly less common than autosomal abnormalities. However, they are usually much less severe in their effects.
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Disorders of sex development DSD are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. To address this we have developed a massively parallel sequencing targeted DSD gene panel which allows us to sequence all 64 known diagnostic DSD genes and candidate genes simultaneously. Our targeted gene panel compares favorably with other sequencing platforms. We found a total of 28 diagnostic genes that are implicated in DSD, highlighting the genetic spectrum of this disorder.
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