Define multicentric disease breast cancer

Multifocal breast cancer occurs when there are two or more tumors in the same breast. All of the tumors begin in one original tumor. The tumors are also all in the same quadrant — or section — of the breast. Multicentric breast cancer is a similar type of cancer.

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Multifocal or Multicentric Breast Cancer: Understanding Its Impact on Management and Treatment Outcomes

Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?

Breast cancer usually begins either in the cells of the lobules, which are milk-producing glands, or the ducts, the passages that drain milk from the lobules to the nipple. The pathology report will tell you whether or not the cancer has spread outside the milk ducts or lobules of the breast where it started. Non-invasive cancers stay within the milk ducts or lobules in the breast. They do not grow into or invade normal tissues within or beyond the breast. Invasive cancers do grow into normal, healthy tissues. Most breast cancers are invasive. Whether the cancer is non-invasive or invasive will determine your treatment choices and how you might respond to the treatments you receive.
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Breast Cancer Multifocality and Multicentricity and Locoregional Recurrence

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Multifocal or multicentric breast cancer can be difficult to detect on mammography or ultrasound, particularly in patients with dense breast tissue. A multimodality approach that includes breast magnetic resonance imaging MRI is indicated, particularly when conservative surgery is being considered as it is the most sensitive technique for identifying additional sites of disease. However, its influence on recurrence and survival rates has yet not been clearly established, and false-positive cases may lead to more aggressive management and treatment. Radiologists should therefore be aware of relevant breast MRI findings.
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